DSIP
Also known as: Delta Sleep-Inducing Peptide · Delta Sleep Peptide
Contents
MW
848.82 Da
Amino Acids
9 AA
Half-Life
7-8 minutes (rapid)
Route
SubQ, IV
CAS
62568-57-4
Formula
C35H48N10O15
Amino Acid Sequence
WAGGDASGE
Mechanism of Action
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (9 amino acids: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit brain during induced sleep. It modulates sleep architecture, particularly slow-wave (delta) sleep.
SLEEP MODULATION: Acts on multiple neuromodulatory systems rather than a single receptor. Modulates GABA-A receptor complex sensitivity, serotonergic tone, and delta opioid receptor systems. Promotes entry into and maintenance of slow-wave (Stage 3/4) sleep — the most restorative sleep phase where GH secretion peaks, memory consolidation occurs, and tissue repair is maximized.
STRESS AXIS: Reduces cortisol and normalizes the hypothalamic-pituitary-adrenal (HPA) axis stress response. Some evidence for anti-stress and adaptogenic effects.
LH MODULATION: Modulates LH (luteinizing hormone) secretion, suggesting hypothalamic interaction.
The exact primary receptor/mechanism remains debated after 40+ years of research — DSIP likely acts as a neuromodulatory peptide affecting multiple systems simultaneously rather than through a single classical receptor-ligand interaction.
Dosing Protocol
Low Dose
███ – ███ mcg/day
Standard Dose
███ mcg/day
High Dose
███ – ███ mcg/day
Dosing protocols are for paid members
Get exact dosing ranges, injection frequency, timing rationale, and reconstitution math.
Get Clinical Access — $79/moFrequency
Once nightly before bed.
Half-Life
7-8 minutes (rapid)
Reconstitution Guide
Full reconstitution protocol with BAC water volumes, concentration math, and units-to-draw per dose is available on the Clinical plan.
Unlock reconstitution guide →Clinical Warnings
Mechanism not fully understood after 40+ years.
Short half-life (~15 min) limits practical efficacy.
Mixed results in clinical studies — reproducibility issues.
Quality concerns from gray-market sources.
Not FDA approved.
Contraindications
Absolute
Pregnancy
Relative Cautions
Epilepsy
Depression
Sleep apnea
Side Effect Profile
Mild
- ●Morning grogginess
- ●Mild headache
Moderate
- ●Oversleeping
- ●Vivid dreams
- ●Transient hypotension
Synergistic Peptides
Common Stacks
Epithalon
Research Status
LIMITED. PMID 6324896 (Schoenenberger 1978): Original DSIP isolation and sleep-promoting activity characterization. PMID 6305877 (Müller 1984): Human REM and slow-wave sleep effects. Mixed reproducibility in clinical studies. Mechanism still debated.
Frequently Asked Questions
How does DSIP work?
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (9 amino acids: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit brain during induced sleep. It modulates sleep architecture, particularly slow-wave (delta) sleep. SLEEP MODULATION: Acts on multiple neuromodulatory systems rather than a single receptor. Modulates GABA-A receptor complex sensitivity, serotonergic tone, and delta opioid receptor systems. Promotes entry into and maintenance of slow-wave (Stage 3/4) sleep — th
What is the standard dose of DSIP?
DSIP dosing protocols are available with a ClinPep Clinical subscription. Dosing varies by indication and patient factors — consult a licensed healthcare provider. General frequency: Once nightly before bed.
What is the half-life of DSIP?
The half-life of DSIP is 7-8 minutes (rapid). This determines optimal dosing frequency and timing.
Who should not use DSIP?
DSIP is absolutely contraindicated in: Pregnancy. Use with caution in: Epilepsy; Depression; Sleep apnea.
What are the side effects of DSIP?
Common mild side effects include: Morning grogginess, Mild headache. Moderate effects: Oversleeping, Vivid dreams, Transient hypotension.
What peptides stack well with DSIP?
DSIP is commonly stacked with: Epithalon, Selank, CJC-1295.
How do you reconstitute DSIP?
DSIP is reconstituted with bacteriostatic water. Exact volumes, concentrations, and units-to-draw calculations are available in the ClinPep Clinical plan. Always follow your compounding pharmacy's instructions.
How long should you cycle DSIP?
DSIP cycle protocols vary by indication. Detailed cycle length, on/off schedules, and monitoring guidelines are available with ClinPep Clinical access. Consult your healthcare provider for personalized cycling guidance.
References & Citations
4 PubMed studies · 3 clinical trials
Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models.
Mu Xiaoxiao, Qu Lijun, Yin Liquan, Wang Libo et al.. Frontiers in pharmacology. 2024
Pichia pastoris-secreted delta sleep inducing peptide and crossing the blood-brain barrier peptides (DSIP-CBBBP) fusion peptides holds significant promise for its potential sleep-enhancing and neurotr
Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.
Tukhovskaya Elena A, Ismailova Alina M, Shaykhutdinova Elvira R, Slashcheva Gulsara A et al.. Molecules (Basel, Switzerland). 2021
Background and Objectives: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral
DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion.
Tukhovskaya Elena A, Shaykhutdinova Elvira R, Ismailova Alina M, Slashcheva Gulsara A et al.. Biomedicines. 2021
A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated u
Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude.
Roy Koustav, Chauhan Garima, Kumari Punita, Wadhwa Meetu et al.. Life sciences. 2018
Sleep loss at high altitude (HA) play major role in worsening of neuropsychological functions, such as attention, memory and decision making. This study investigates the role of phosphorylated delta s
Registered Clinical Trials
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Symptom Indications
Full Clinical Access
Complete DSIP Protocol
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This information is for educational and research reference purposes only. ClinPep does not provide medical advice, diagnosis, or treatment recommendations. All protocols should be reviewed by a licensed healthcare provider.