AOD-9604
Also known as: Anti-Obesity Drug 9604 · Advanced Obesity Drug · Tyr-hGH fragment 177-191
Contents
MW
1817.12 Da
Amino Acids
15 AA
Half-Life
30-45 minutes
Route
SubQ
CAS
221231-10-3
Formula
C78H125N19O23S2
Mechanism of Action
AOD-9604 is a synthetic peptide corresponding to the C-terminal fragment (amino acids 176-191) of human growth hormone. It retains the lipolytic (fat-burning) activity of GH without activating the GH receptor for growth-promoting effects.
PRIMARY MECHANISM — β3-ADRENERGIC ACTIVATION: Mimics the lipolytic domain of GH, activating β3-adrenergic receptors on adipocytes → adenylyl cyclase → cAMP → hormone-sensitive lipase (HSL) activation → triglyceride hydrolysis into free fatty acids and glycerol for energy use.
CRITICAL DISTINCTION — NO IGF-1 ACTIVATION: Does NOT activate the IGF-1 receptor (unlike full-length GH). This means no diabetogenic effects, no acromegalic changes, no mitogenic (cancer-promoting) risk from IGF-1 elevation. This selective lipolytic action is the primary advantage.
LIPOGENESIS INHIBITION: Blocks de novo fatty acid synthesis by inhibiting acetyl-CoA carboxylase and fatty acid synthase in adipocytes, reducing new fat storage.
REGULATORY STATUS: The Australian TGA (Therapeutic Goods Administration) granted GRAS (Generally Recognized As Safe) status for oral AOD-9604, enabling its use in food/supplement formulations in Australia.
AOD-9604, Fragment 176-191, and HGH Frag 176-191 are the same compound — different names for the identical 16-amino acid C-terminal fragment of human growth hormone.
Dosing Protocol
Low Dose
███ – ███ mcg/day
Standard Dose
███ mcg/day
High Dose
███ – ███ mcg/day
Dosing protocols are for paid members
Get exact dosing ranges, injection frequency, timing rationale, and reconstitution math.
Get Clinical Access — $79/moFrequency
Once daily SubQ, morning fasted.
Half-Life
30-45 minutes
Reconstitution Guide
Full reconstitution protocol with BAC water volumes, concentration math, and units-to-draw per dose is available on the Clinical plan.
Unlock reconstitution guide →Clinical Warnings
Not FDA approved.
Limited human clinical data.
No muscle/bone anabolic effects (pure lipolytic).
WADA prohibited.
Does not replace exercise/diet for weight management.
Contraindications
Absolute
Pregnancy
Active cancer
Relative Cautions
Diabetes
Thyroid disorders
Side Effect Profile
Mild
- ●Injection site reaction
- ●Mild headache
Moderate
- ●Nausea
- ●Indigestion
Synergistic Peptides
Common Stacks
Fragment 176-191
CJC-1295
Research Status
LIMITED HUMAN DATA. Heffernan 2001 (PMID 11713213): hGH fragment lipolysis in obese subjects. Ng 2000 (PMID 15665062): AOD-9604 vs hGH lipolytic activity comparison. TGA GRAS for oral formulation. No Phase III RCTs completed.
Frequently Asked Questions
How does AOD-9604 work?
AOD-9604 is a synthetic peptide corresponding to the C-terminal fragment (amino acids 176-191) of human growth hormone. It retains the lipolytic (fat-burning) activity of GH without activating the GH receptor for growth-promoting effects. PRIMARY MECHANISM — β3-ADRENERGIC ACTIVATION: Mimics the lipolytic domain of GH, activating β3-adrenergic receptors on adipocytes → adenylyl cyclase → cAMP → hormone-sensitive lipase (HSL) activation → triglyceride hydrolysis into free fatty acids and glycerol
What is the standard dose of AOD-9604?
AOD-9604 dosing protocols are available with a ClinPep Clinical subscription. Dosing varies by indication and patient factors — consult a licensed healthcare provider. General frequency: Once daily SubQ, morning fasted.
What is the half-life of AOD-9604?
The half-life of AOD-9604 is 30-45 minutes. This determines optimal dosing frequency and timing.
Who should not use AOD-9604?
AOD-9604 is absolutely contraindicated in: Pregnancy; Active cancer. Use with caution in: Diabetes; Thyroid disorders.
What are the side effects of AOD-9604?
Common mild side effects include: Injection site reaction, Mild headache. Moderate effects: Nausea, Indigestion.
What peptides stack well with AOD-9604?
AOD-9604 is commonly stacked with: Fragment 176-191, CJC-1295, Ipamorelin, Semaglutide.
How do you reconstitute AOD-9604?
AOD-9604 is reconstituted with bacteriostatic water. Exact volumes, concentrations, and units-to-draw calculations are available in the ClinPep Clinical plan. Always follow your compounding pharmacy's instructions.
How long should you cycle AOD-9604?
AOD-9604 cycle protocols vary by indication. Detailed cycle length, on/off schedules, and monitoring guidelines are available with ClinPep Clinical access. Consult your healthcare provider for personalized cycling guidance.
References & Citations
2 PubMed studies · 0 clinical trials
The effects of human GH and its lipolytic fragment on lipid metabolism
Heffernan M et al.. Int J Obes. 2001
Metabolic effects of human growth hormone fragment 176-191
Ng FM et al.. Endocrinology. 2000
Symptom Indications
Full Clinical Access
Complete AOD-9604 Protocol
Access reconstitution math, cycle guides, drug interaction checker, stack builder with contraindication analysis, symptom checker, and downloadable PDF handouts.
Secure payment powered by Stripe.
This information is for educational and research reference purposes only. ClinPep does not provide medical advice, diagnosis, or treatment recommendations. All protocols should be reviewed by a licensed healthcare provider.