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● Reference

Database.

Evidence-based clinical reference monographs for 61 therapeutic peptides. Mechanisms of action, dosing protocols, contraindications, and PubMed-cited research.

61

Peptides

12

Categories

60+

Conditions

600+

Citations

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Anti-Aging

6 peptides
  • Epithalon

    t½ ~30 minutes

    Epitalon

    Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on Epithalamin, a natural polypeptide extract of the pineal gland.

    Anti-AgingView →
  • GHK-Cu

    t½ ~1 hour

    Copper Tripeptide-1

    GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine.

    Anti-AgingView →
  • Glutathione

    t½ ~14 minutes

    GSH

    Glutathione (GSH) is a tripeptide (Glu-Cys-Gly) and the most abundant intracellular antioxidant in the human body.

    Anti-AgingView →
  • Humanin

    See FDA prescribing information and PubMed citations.

    Anti-AgingView →
  • NAD+

    t½ ~10 minutes

    NAD+

    NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in every living cell, required for >500 enzymatic reactions.

    Anti-AgingView →
  • Pinealon

    See references.

    Anti-AgingView →

Anti-Inflammatory

4 peptides
  • ARA-290

    t½ ~2 minutes

    Cibinetide

    ARA-290 (Cibinetide) is an 11-amino acid peptide derived from the B helix of erythropoietin (EPO).

    Anti-InflammatoryView →
  • KPV

    t½ ~20 minutes

    KPV tripeptide

    KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-melanocyte stimulating hormone (α-MSH).

    Anti-InflammatoryView →
  • Larazotide Acetate

    The intestinal barrier, a critical component of the body's defense system, plays a vital role in maintaining homeostasis by preventing the translocation of harmful substances from the gut lumen into the bloodstream.

    Anti-InflammatoryView →
  • VIP

    t½ ~2 minutes

    Vasoactive Intestinal Peptide

    VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide that binds VPAC1 and VPAC2 receptors (Gs-coupled → adenylyl cyclase → cAMP).

    Anti-InflammatoryView →

Antimicrobial

1 peptides
  • LL-37

    t½ ~30 minutes

    Cathelicidin

    LL-37 is the sole human cathelicidin — a 37-amino acid antimicrobial peptide naturally produced by neutrophils, epithelial cells, macrophages, and keratinocytes in response to infection and tissue injury.

    AntimicrobialView →

Growth Hormone

17 peptides
  • AOD-9604

    t½ ~30 minutes

    AOD9604

    AOD-9604 is a synthetic peptide corresponding to the C-terminal fragment (amino acids 176-191) of human growth hormone.

    Growth HormoneView →
  • CJC-1295

    t½ ~30 minutes

    Mod GRF 1-29

    CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid analog of endogenous GHRH (growth hormone-releasing hormone).

    Growth HormoneView →
  • CJC-1295 with DAC

    t½ 6-8 days

    CJC-1295 with DAC

    CJC-1295 with DAC (Drug Affinity Complex) is the same GHRH analog as CJC-1295 no-DAC but with a DAC moiety (a reactive amine that covalently binds to albumin after injection).

    Growth HormoneView →
  • Follistatin-344

    t½ ~6 hours

    FS-344

    Follistatin-344 is a 344-amino acid glycoprotein that functions as a potent inhibitor of myostatin (GDF-8) and activin A — both TGF-β superfamily members that act as endogenous brakes on muscle growth.

    Growth HormoneView →
  • Fragment 176-191

    t½ ~30 minutes

    hGH Frag 176-191

    Fragment 176-191 (HGH Frag 176-191) is the C-terminal fragment of human growth hormone corresponding to amino acids 176-191.

    Growth HormoneView →
  • GHRP-1

    Growth hormone releasing peptides (GHRPs) could be widely used by cheating athletes because they produce growth hormone (GH) secretion, so may generate an ergogenic effect in the body.

    Growth HormoneView →
  • GHRP-2

    t½ ~55 minutes

    Pralmorelin

    GHRP-2 (Growth Hormone Releasing Peptide-2, Pralmorelin) is a synthetic hexapeptide GH secretagogue that binds GHS-R1a on pituitary somatotrophs.

    Growth HormoneView →
  • GHRP-6

    t½ ~50 minutes

    Growth Hormone Releasing Peptide 6

    GHRP-6 (Growth Hormone Releasing Peptide-6) is the original clinically studied GHRP — a synthetic hexapeptide that binds GHS-R1a.

    Growth HormoneView →
  • Hexarelin

    t½ ~55 minutes

    HEX

    Hexarelin is a synthetic hexapeptide and the MOST POTENT GH-releasing peptide per-dose among all GHRPs.

    Growth HormoneView →
  • IGF-1 LR3

    t½ ~20-30 hours

    Long R3 IGF-1

    IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified IGF-1 with an arginine substitution at position 3 and a 13-amino acid N-terminal extension.

    Growth HormoneView →
  • Ipamorelin

    t½ ~2 hours

    NNC 26-0161

    Ipamorelin is a synthetic pentapeptide and the most selective growth hormone releasing peptide (GHRP) discovered.

    Growth HormoneView →
  • Macimorelin

    t½ 4.1 hours

    Macrilen

    12.

    Growth HormoneView →
  • MK-677

    t½ ~6 hours

    Ibutamoren

    MK-677 (Ibutamoren) is a non-peptide, orally active ghrelin mimetic that activates GHS-R1a.

    Growth HormoneView →
  • PEG-MGF

    t½ ~2-3 days

    PEGylated Mechano Growth Factor

    PEG-MGF (PEGylated Mechano Growth Factor) is the PEGylated form of MGF, a splice variant of IGF-1 produced specifically in response to mechanical stress (exercise, injury).

    Growth HormoneView →
  • Recombinant Human Growth Hormone

    t½ ~3-4 hours

    Somatropin

    Recombinant 191-amino acid somatropin identical to pituitary growth hormone.

    Growth HormoneView →
  • Sermorelin

    t½ 10-20 minutes

    GRF 1-29

    Sermorelin (GHRH 1-29) is a synthetic 29-amino acid peptide corresponding to the first 29 amino acids of endogenous GHRH — the biologically active portion.

    Growth HormoneView →
  • Tesamorelin

    t½ ~26-38 minutes

    Egrifta

    Tesamorelin is a synthetic 44-amino acid GHRH analog — the ONLY GHRH analog currently FDA-approved for any indication.

    Growth HormoneView →

Hormonal

8 peptides
  • Desmopressin

    t½ 2.8 hours

    DDAVP

    12.

    HormonalView →
  • Gonadorelin

    Factrel

    Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal (HPG) axis.

    HormonalView →
  • Goserelin

    Zoladex

    12.

    HormonalView →
  • Kisspeptin

    t½ ~28 minutes

    Kisspeptin-54

    Kisspeptin is a hypothalamic neuropeptide encoded by the KISS1 gene that serves as the master regulator of the reproductive axis.

    HormonalView →
  • Kisspeptin-54

    Gonadotropin-releasing hormone (GnRH) is the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, and therefore of fertility and reproduction.

    HormonalView →
  • Leuprolide

    t½ 3 hours

    Lupron

    12.

    HormonalView →
  • Oxytocin

    t½ ~5-10 minutes

    Pitocin

    Oxytocin is a 9-amino acid neuropeptide produced in the hypothalamic paraventricular and supraoptic nuclei.

    HormonalView →
  • Triptorelin

    Trelstar

    12.

    HormonalView →

Immune

3 peptides
  • Thymalin

    t½ ~30 minutes

    Thymus extract

    A fraction of polypeptides extracted from calf or porcine thymus that promotes differentiation and maturation of T-lymphocytes.

    ImmuneView →
  • Thymopentin (TP-5)

    Background/Objectives: T cell dysfunction represents a fundamental barrier to effective cancer immunotherapy.

    ImmuneView →
  • Thymosin Alpha-1

    t½ 2 hours

    Tα1

    Thymosin Alpha-1 (Tα1) is a 28-amino acid peptide naturally produced in the thymus gland.

    ImmuneView →

Metabolic

8 peptides
  • 5-Amino-1MQ

    t½ ~6 hours

    5-Amino-1MQ

    5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule inhibitor of NNMT (nicotinamide N-methyltransferase).

    MetabolicView →
  • Cagrilintide

    t½ ~7-8 days

    AM833

    Cagrilintide is a long-acting acylated amylin analog designed for once-weekly subcutaneous injection.

    MetabolicView →
  • Dulaglutide

    t½ 5 days

    Trulicity

    12.

    MetabolicView →
  • Exenatide

    t½ 2.4 hours

    Byetta

    12.

    MetabolicView →
  • Liraglutide

    Victoza

    12.

    MetabolicView →
  • Retatrutide

    t½ ~6 days

    LY3437943

    Retatrutide is the first triple incretin receptor agonist, simultaneously activating GLP-1R, GIPR (glucose-dependent insulinotropic polypeptide receptor), and GcgR (glucagon receptor).

    MetabolicView →
  • Semaglutide

    t½ ~1 week

    Ozempic

    Semaglutide is a long-acting synthetic GLP-1 receptor agonist sharing 94% sequence homology with native GLP-1.

    MetabolicView →
  • Tirzepatide

    t½ ~5 days

    Mounjaro

    Tirzepatide is a synthetic 39-amino acid dual GLP-1/GIP receptor agonist.

    MetabolicView →

Mitochondrial

2 peptides
  • MOTS-c

    t½ ~2 hours

    MOTS-c

    MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino acid peptide encoded in the mitochondrial genome.

    MitochondrialView →
  • SS-31

    t½ ~3-6 hours

    Elamipretide

    SS-31 (Elamipretide, Bendavia, MTP-131) is a tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that selectively targets the inner mitochondrial membrane, concentrating >1,000-fold in mitochondria due to its alternating aromatic-cationic structure.

    MitochondrialView →

Musculoskeletal

1 peptides
  • Calcitonin Salmon

    t½ 59 to

    Miacalcin

    12.

    MusculoskeletalView →

Neurological

6 peptides
  • Cerebrolysin

    t½ ~6 hours

    FPF-1070

    Cerebrolysin is a porcine brain-derived peptide preparation containing enzymatically processed low-molecular-weight neuropeptides and free amino acids.

    NeurologicalView →
  • Dihexa

    t½ ~10 hours

    N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

    Dihexa is a hexapeptide derived from angiotensin IV that activates the HGF (hepatocyte growth factor) / c-Met receptor pathway.

    NeurologicalView →
  • DSIP

    t½ ~7 minutes

    Delta Sleep Inducing Peptide

    DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (9 amino acids: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit brain during induced sleep.

    NeurologicalView →
  • Noopept (GVS-111)

    See FDA prescribing information and PubMed citations.

    NeurologicalView →
  • Selank

    t½ ~30 minutes

    Selanc

    Selank is a synthetic heptapeptide derived from the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro C-terminal extension for enzymatic stability.

    NeurologicalView →
  • Semax

    t½ ~30 minutes

    Semaks

    Semax is a synthetic heptapeptide analog of ACTH fragment 4-7 (Met-Glu-His-Phe) with Pro-Gly-Pro C-terminal extension.

    NeurologicalView →

Sexual Health

2 peptides
  • Melanotan II

    t½ ~33 hours

    MT-II

    Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of α-MSH (alpha-melanocyte stimulating hormone).

    Sexual HealthView →
  • PT-141

    t½ 2.7 hours

    Bremelanotide

    PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist, primarily targeting MC4R.

    Sexual HealthView →

Tissue Repair

3 peptides
  • BPC-157

    t½ 4-6 hours

    Body Protection Compound

    BPC-157 is a 15-amino acid pentadecapeptide derived from a cytoprotective protein in human gastric juice.

    Tissue RepairView →
  • TB-500

    t½ 2-3 hours

    Thymosin Beta-4 Fragment

    TB-500 is the synthetic, injectable actin-binding fragment of Thymosin Beta-4 (Tβ4), corresponding to the 16-amino acid LKKTETQ-containing region responsible for Tβ4's biological activity.

    Tissue RepairView →
  • TB4-FRAG

    The immunomodulatory, anti-inflammatory and regenerative properties of the human amniotic mesenchymal stromal cells (hAMSCs) secretome are acknowledged but the understanding of the specific bioactive components remains incomplete.

    Tissue RepairView →

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