5-Amino-1MQ
Also known as: 5-amino-1-methylquinolinium · 5A1MQ
Contents
MW
174.2 Da
Half-Life
8-12 hours
Route
SubQ, Oral
CAS
27582-20-1
Formula
C10H10N2O
Mechanism of Action
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule inhibitor of NNMT (nicotinamide N-methyltransferase). Despite being included in peptide databases, it is technically a small molecule, not a peptide.
PRIMARY MECHANISM — NNMT INHIBITION: NNMT methylates nicotinamide (a NAD+ precursor) using SAM (S-adenosylmethionine) as a methyl donor. NNMT is upregulated in obesity and metabolic syndrome, particularly in white adipose tissue. By inhibiting NNMT:
(1) NAD+ BIOSYNTHESIS INCREASE: More nicotinamide is available for conversion to NAD+ via the salvage pathway → increased cellular NAD+ → enhanced sirtuin activity and mitochondrial function.
(2) SAM CONSERVATION: More SAM available for other methylation reactions (DNA methylation, histone modification, neurotransmitter synthesis).
(3) REDUCED ADIPOGENESIS: NNMT inhibition directly reduces adipocyte differentiation and lipid accumulation.
(4) INCREASED ENERGY EXPENDITURE: In mouse models, NNMT inhibition reduced body weight WITHOUT reducing food intake — indicating increased metabolic rate rather than appetite suppression.
The NNMT-NAD+-SAM axis connects obesity, epigenetics, and metabolic function in a single pathway.
Dosing Protocol
Low Dose
███ – ███ mcg/day
Standard Dose
███ mcg/day
High Dose
███ – ███ mcg/day
Dosing protocols are for paid members
Get exact dosing ranges, injection frequency, timing rationale, and reconstitution math.
Get Clinical Access — $79/moFrequency
Daily.
Half-Life
8-12 hours
Reconstitution Guide
Full reconstitution protocol with BAC water volumes, concentration math, and units-to-draw per dose is available on the Clinical plan.
Unlock reconstitution guide →Clinical Warnings
NO HUMAN DATA — entirely preclinical.
NNMT has roles in liver, brain — systemic effects unknown.
NAD+ and SAM metabolism disruption possible.
Not FDA approved.
Research chemical only.
Long-term safety completely unknown.
Contraindications
Absolute
Pregnancy
Relative Cautions
Liver disease
Kidney disease
Side Effect Profile
Mild
- ●Mild nausea
- ●Headache
Moderate
- ●GI discomfort
- ●Fatigue
Synergistic Peptides
Common Stacks
NAD+
SS-31
Research Status
PRECLINICAL ONLY. PMID 34793726 (Dixit 2021): NNMT inhibition reduced adipogenesis in mice. Zero human clinical trials. Mechanism well-characterized but therapeutic translation unproven.
Frequently Asked Questions
How does 5-Amino-1MQ work?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule inhibitor of NNMT (nicotinamide N-methyltransferase). Despite being included in peptide databases, it is technically a small molecule, not a peptide. PRIMARY MECHANISM — NNMT INHIBITION: NNMT methylates nicotinamide (a NAD+ precursor) using SAM (S-adenosylmethionine) as a methyl donor. NNMT is upregulated in obesity and metabolic syndrome, particularly in white adipose tissue. By inhibiting NNMT: (1) NAD+ BIOSYNTHESIS INCREASE: More
What is the standard dose of 5-Amino-1MQ?
5-Amino-1MQ dosing protocols are available with a ClinPep Clinical subscription. Dosing varies by indication and patient factors — consult a licensed healthcare provider. General frequency: Daily.
What is the half-life of 5-Amino-1MQ?
The half-life of 5-Amino-1MQ is 8-12 hours. This determines optimal dosing frequency and timing.
Who should not use 5-Amino-1MQ?
5-Amino-1MQ is absolutely contraindicated in: Pregnancy. Use with caution in: Liver disease; Kidney disease.
What are the side effects of 5-Amino-1MQ?
Common mild side effects include: Mild nausea, Headache. Moderate effects: GI discomfort, Fatigue.
What peptides stack well with 5-Amino-1MQ?
5-Amino-1MQ is commonly stacked with: NAD+, SS-31, AOD-9604.
How do you reconstitute 5-Amino-1MQ?
5-Amino-1MQ is reconstituted with bacteriostatic water. Exact volumes, concentrations, and units-to-draw calculations are available in the ClinPep Clinical plan. Always follow your compounding pharmacy's instructions.
How long should you cycle 5-Amino-1MQ?
5-Amino-1MQ cycle protocols vary by indication. Detailed cycle length, on/off schedules, and monitoring guidelines are available with ClinPep Clinical access. Consult your healthcare provider for personalized cycling guidance.
References & Citations
1 PubMed studies · 0 clinical trials
Pharmacological inhibition of NNMT reduces adiposity and body weight
Dixit D et al.. Biochem Biophys Res Commun. 2021
Symptom Indications
Full Clinical Access
Complete 5-Amino-1MQ Protocol
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This information is for educational and research reference purposes only. ClinPep does not provide medical advice, diagnosis, or treatment recommendations. All protocols should be reviewed by a licensed healthcare provider.