Hexarelin
Also known as: Examorelin · HEX
Contents
MW
887.04 Da
Amino Acids
6 AA
Half-Life
70 minutes
Route
SubQ, IV
CAS
140703-51-1
Formula
C47H58N10O6
Amino Acid Sequence
His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH2
Mechanism of Action
Hexarelin is a synthetic hexapeptide and the MOST POTENT GH-releasing peptide per-dose among all GHRPs. It binds GHS-R1a to produce robust GH secretion.
PRIMARY MECHANISM: GHS-R1a activation → Gq → PLC → calcium → GH exocytosis. Same pathway as ipamorelin, GHRP-2, and GHRP-6 but with the highest intrinsic activity at the receptor.
UNIQUE FEATURE — CD36 RECEPTOR BINDING: Hexarelin is the ONLY GHRP that also binds CD36 scavenger receptor on cardiomyocytes. CD36 activation provides direct cardioprotective effects independent of GH release — reduced myocardial fibrosis, improved cardiac function after ischemia, and anti-atherosclerotic effects. This dual receptor activity makes hexarelin uniquely valuable for cardiac applications.
SIDE EFFECT PROFILE: Cortisol and prolactin elevation similar to GHRP-6 — not selective like ipamorelin.
RAPID DESENSITIZATION: Hexarelin shows faster GHS-R1a receptor desensitization than other GHRPs. Efficacy declines within weeks of continuous use, requiring shorter cycles and longer off-periods. This rapid tolerance is the main clinical limitation.
Dosing Protocol
Low Dose
███ – ███ mcg/day
Standard Dose
███ mcg/day
High Dose
███ – ███ mcg/day
Dosing protocols are for paid members
Get exact dosing ranges, injection frequency, timing rationale, and reconstitution math.
Get Clinical Access — $79/moFrequency
2–3x daily.
Half-Life
70 minutes
Reconstitution Guide
Full reconstitution protocol with BAC water volumes, concentration math, and units-to-draw per dose is available on the Clinical plan.
Unlock reconstitution guide →Clinical Warnings
Rapid receptor desensitization — efficacy declines within weeks.
Cortisol/prolactin elevation (not selective).
Short practical cycle length.
WADA prohibited.
Cancer contraindication.
Not selective like ipamorelin.
Contraindications
Absolute
Active cancer
Pregnancy
Relative Cautions
Diabetes
Heart disease
Cushing syndrome
History of cancer
Side Effect Profile
Mild
- ●Increased appetite
- ●Water retention
- ●Flushing
Moderate
- ●Elevated cortisol
- ●Elevated prolactin
- ●Headache
- ●Lethargy
Severe (Rare)
- ●Tachyphylaxis (desensitization)
- ●Potential tumor growth
Synergistic Peptides
Common Stacks
CJC-1295
GHRP-2
Research Status
MODERATE. PMID 9487038 (Ghigo 1997): Hexarelin potency comparison — most potent GHRP. PMID 11113074 (Muccioli 2001): CD36 cardioprotective receptor binding — unique to hexarelin. Rapid desensitization limits practical use.
Frequently Asked Questions
How does Hexarelin work?
Hexarelin is a synthetic hexapeptide and the MOST POTENT GH-releasing peptide per-dose among all GHRPs. It binds GHS-R1a to produce robust GH secretion. PRIMARY MECHANISM: GHS-R1a activation → Gq → PLC → calcium → GH exocytosis. Same pathway as ipamorelin, GHRP-2, and GHRP-6 but with the highest intrinsic activity at the receptor. UNIQUE FEATURE — CD36 RECEPTOR BINDING: Hexarelin is the ONLY GHRP that also binds CD36 scavenger receptor on cardiomyocytes. CD36 activation provides direct cardiop
What is the standard dose of Hexarelin?
Hexarelin dosing protocols are available with a ClinPep Clinical subscription. Dosing varies by indication and patient factors — consult a licensed healthcare provider. General frequency: 2–3x daily.
What is the half-life of Hexarelin?
The half-life of Hexarelin is 70 minutes. This determines optimal dosing frequency and timing.
Who should not use Hexarelin?
Hexarelin is absolutely contraindicated in: Active cancer; Pregnancy. Use with caution in: Diabetes; Heart disease; Cushing syndrome.
What are the side effects of Hexarelin?
Common mild side effects include: Increased appetite, Water retention, Flushing. Moderate effects: Elevated cortisol, Elevated prolactin, Headache, Lethargy.
What peptides stack well with Hexarelin?
Hexarelin is commonly stacked with: CJC-1295, GHRP-2, GHRP-6.
How do you reconstitute Hexarelin?
Hexarelin is reconstituted with bacteriostatic water. Exact volumes, concentrations, and units-to-draw calculations are available in the ClinPep Clinical plan. Always follow your compounding pharmacy's instructions.
How long should you cycle Hexarelin?
Hexarelin cycle protocols vary by indication. Detailed cycle length, on/off schedules, and monitoring guidelines are available with ClinPep Clinical access. Consult your healthcare provider for personalized cycling guidance.
References & Citations
1 PubMed studies · 0 clinical trials
Identification of alexamorelin consumption biomarkers using human hepatocyte incubations and high-resolution mass spectrometry.
Pobee Elizabeth, Daziani Gloria, Gameli Prince S, Basile Giuseppe et al.. Journal of analytical toxicology. 2025
Alexamorelin is a synthetic peptide and growth hormone secretagogue (GHS) with potential performance-enhancing properties, making its use and abuse a topic of interest in clinical research and doping
Symptom Indications
Full Clinical Access
Complete Hexarelin Protocol
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This information is for educational and research reference purposes only. ClinPep does not provide medical advice, diagnosis, or treatment recommendations. All protocols should be reviewed by a licensed healthcare provider.