IGF-1 LR3

Provisional Treatment of Volumetric Muscle Loss With Insulin-like Growth Factor 1 Releasing Muscle Void Fillers.

Clark Andrew R, Adams Alex T, McKinley Todd O, Natoli Roman M et al.. The Journal of surgical research. 2026

Volumetric muscle loss (VML) resulting from severe extremity injuries in combat remains a significant clinical challenge, particularly in austere environments. Current research emphasizes the developm

Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.

Yavuz Ersin, Sağır Melih S, Ercan Alp, Erginer Merve et al.. International journal of biological macromolecules. 2025

Peripheral nerve injuries lead to significant functional deficits, with no treatment achieving complete recovery. Autologous nerve grafting remains the gold standard, but it is limited by donor site m

IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.

White Alicia, Stremming Jane, Wesolowski Stephanie R, Al-Juboori Saif I et al.. American journal of physiology. Endocrinology and metabolism. 2025

Insulin-like growth factor-1 (IGF-1) and insulin are important fetal anabolic hormones. Complications of pregnancy, such as placental insufficiency, can lead to fetal growth restriction (FGR) with low

Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.

Engel Matthew G, Narayan Sushma, Cui Min-Hui, Branch Craig A et al.. Journal of Alzheimer's disease : JAD. 2025

Insulin-like growth factor-1 (IGF-1) promotes neurogenesis, cell survival, and glial function, making it a promising candidate therapy in Alzheimer's disease (AD). Long arginine 3-IGF-1 (LR3-IGF-1) is

Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.

Lu Zequn, Liu Ning, Huang Huoqing, Wang Yuan et al.. Applied microbiology and biotechnology. 2023

Insulin-like growth factor-1 (IGF-1) is a pleiotropic protein hormone and has become an attractive therapeutic target because of its multiple roles in various physiological processes, including growth

Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.

White Alicia, Stremming Jane, Brown Laura D, Rozance Paul J. Journal of developmental origins of health and disease. 2023

Insulin-like growth factor-1 (IGF-1) is a critical fetal growth hormone that has been proposed as a therapy for intrauterine growth restriction. We previously demonstrated that a 1-week IGF-1 LR3 infu

N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling.

Salvi Rupashree, Kumar Chandan, Brahmbhatt Krupanshi, Subedi Rambhadur et al.. International journal of molecular sciences. 2022

Cell surface proteins carrying N-glycans play important roles in inter- and intracellular processes including cell adhesion, development, and cellular recognition. Dysregulation of the glycosylation m

Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.

White Alicia, Stremming Jane, Boehmer Brit H, Chang Eileen I et al.. American journal of physiology. Endocrinology and metabolism. 2021

Insulin and insulin-like growth factor-1 (IGF-1) are fetal hormones critical to establishing normal fetal growth. Experimentally elevated IGF-1 concentrations during late gestation increase fetal weig