Selank
Also known as: TP-7 · Selanc
Contents
MW
751.9 Da
Amino Acids
7 AA
Half-Life
2-3 minutes (intranasal, rapid CNS absorption)
Route
Intranasal, SubQ
CAS
129954-34-3
Formula
C33H57N11O9
Amino Acid Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Mechanism of Action
Selank is a synthetic heptapeptide derived from the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro C-terminal extension for enzymatic stability. It is approved in Russia as an anxiolytic nasal spray.
BDNF UPREGULATION: Increases BDNF (brain-derived neurotrophic factor) expression in hippocampus → enhanced neuroplasticity, neurogenesis, and synaptic strengthening. This provides the anxiolytic effect through neuroplastic remodeling rather than sedation.
IL-6 MODULATION: Unique bidirectional IL-6 regulation — normalizes both elevated and suppressed IL-6 levels. This immune-balancing effect connects to its tuftsin origin (tuftsin is an immune regulator).
GABAergic MODULATION: Enhances GABA-A receptor sensitivity without direct agonism — increases inhibitory tone without producing sedation, cognitive impairment, or dependence (unlike benzodiazepines).
ENKEPHALINASE INHIBITION: Inhibits enkephalin-degrading enzymes → increased endogenous opioid peptide tone → anxiolysis and mild mood elevation.
The combination of BDNF-mediated neuroplasticity + GABAergic modulation + endogenous opioid enhancement produces anxiolysis without sedation — a unique mechanism distinct from any Western-approved anxiolytic.
Dosing Protocol
Low Dose
███ – ███ mcg/day
Standard Dose
███ mcg/day
High Dose
███ – ███ mcg/day
Dosing protocols are for paid members
Get exact dosing ranges, injection frequency, timing rationale, and reconstitution math.
Get Clinical Access — $79/moFrequency
2–3x daily intranasal.
Half-Life
2-3 minutes (intranasal, rapid CNS absorption)
Reconstitution Guide
Full reconstitution protocol with BAC water volumes, concentration math, and units-to-draw per dose is available on the Clinical plan.
Unlock reconstitution guide →Clinical Warnings
Almost exclusively Russian research.
Not FDA approved.
Intranasal bioavailability varies.
Not a benzodiazepine replacement for acute panic.
Quality concerns outside Russia.
Contraindications
Absolute
Pregnancy
Relative Cautions
Autoimmune conditions
Current SSRI therapy
Side Effect Profile
Mild
- ●Mild fatigue
- ●Nasal irritation (intranasal)
Moderate
- ●Headache
- ●Drowsiness
Synergistic Peptides
Common Stacks
Semax
Research Status
APPROVED IN RUSSIA. PMID 17450476 (Semenova 2010): Anxiolytic effects in anxiety patients. PMID 24830283 (Kozlovskaya 2014): BDNF and IL-6 modulation. Limited Western research.
Frequently Asked Questions
How does Selank work?
Selank is a synthetic heptapeptide derived from the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro C-terminal extension for enzymatic stability. It is approved in Russia as an anxiolytic nasal spray. BDNF UPREGULATION: Increases BDNF (brain-derived neurotrophic factor) expression in hippocampus → enhanced neuroplasticity, neurogenesis, and synaptic strengthening. This provides the anxiolytic effect through neuroplastic remodeling rather than sedation.
What is the standard dose of Selank?
Selank dosing protocols are available with a ClinPep Clinical subscription. Dosing varies by indication and patient factors — consult a licensed healthcare provider. General frequency: 2–3x daily intranasal.
What is the half-life of Selank?
The half-life of Selank is 2-3 minutes (intranasal, rapid CNS absorption). This determines optimal dosing frequency and timing.
Who should not use Selank?
Selank is absolutely contraindicated in: Pregnancy. Use with caution in: Autoimmune conditions; Current SSRI therapy.
What are the side effects of Selank?
Common mild side effects include: Mild fatigue, Nasal irritation (intranasal). Moderate effects: Headache, Drowsiness.
What peptides stack well with Selank?
Selank is commonly stacked with: Semax, BPC-157, NAD+.
How do you reconstitute Selank?
Selank is reconstituted with bacteriostatic water. Exact volumes, concentrations, and units-to-draw calculations are available in the ClinPep Clinical plan. Always follow your compounding pharmacy's instructions.
How long should you cycle Selank?
Selank cycle protocols vary by indication. Detailed cycle length, on/off schedules, and monitoring guidelines are available with ClinPep Clinical access. Consult your healthcare provider for personalized cycling guidance.
References & Citations
5 PubMed studies · 3 clinical trials
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Konstantinopolsky M A, Chernyakova I V, Kolik L G. Bulletin of experimental biology and medicine. 2022
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model. Single intraperitoneal injection of Selank in an anxiolytic dose of
Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.
Doyno Cassandra R, White C Michael. Journal of clinical pharmacology. 2021
There are many nonopioid central nervous system depressant substances that share a gamma-aminobutyric acid (GABA) receptor-related mechanism of action. These sedatives-hypnotics can be indicated to tr
Functional Connectomic Approach to Studying Selank and Semax Effects.
Panikratova Ya R, Lebedeva I S, Sokolov O Yu, Rumshiskaya A D et al.. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 2020
The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of int
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.
Kolik L G, Nadorova A V, Antipova T A, Kruglov S V et al.. Bulletin of experimental biology and medicine. 2019
The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures w
Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.
Vyunova Tatiana V, Andreeva Lioudmila, Shevchenko Konstantin, Myasoedov Nikolay. Protein and peptide letters. 2018
Anxiety and mood disorders are the most abundant mental health problems worldwide. The commonly used in clinical practice anxiolytics are focused on pharmacological modulation of brain GABA receptor s
Registered Clinical Trials
The Effect of Balance Exercises on Cognitive Function
Trial of Telephone-based Psychotherapy for Depression With and Without Adjunctive Supportive Mail
Neural Mechanisms and Efficacy of Imagery Rescripting for Fear of Failure
Symptom Indications
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Complete Selank Protocol
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This information is for educational and research reference purposes only. ClinPep does not provide medical advice, diagnosis, or treatment recommendations. All protocols should be reviewed by a licensed healthcare provider.